Waller-Bridge grew up in Ealing in west London, and is an alumna of RADA.She attended private sixth form college DLD in Marylebone, London, before making her stage debut in 2009. She is the co-artistic director of DryWrite theatre company. Besides acting, she has also scripted plays, including Good. Clean. Fun. and Fleabag. Waller-Bridge appeared in the second season of drama Broadchurch.
In 2016, she wrote and starred in two sitcoms, Channel 4's Crashing and BBC Three's Fleabag.
She lives in Kensal Rise, London, with her husband Conor Woodman(born 21 March 1974) is an Irish director, television presenter, author and public speaker..
She won two WhatsOnStage Awards and a The Stage awards in 2013.